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KMID : 1007020090070010035
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Korean Soceity of Osteroporosis
2009 Volume.7 No. 1 p.35 ~ p.42
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The Effect of Hormone Replacement Therapy on Bone Mineral Density in Korean Postmenopausal Women for 2 Years
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Oh Han-Jin
Yang Seoung-Oh
Jung Jee-Young
Jung Hyuk
Kim Heung-Yeol
Jung Min-Hyung
Oh Jee-Young
Kim Mi-Hyang
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Abstract
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Objectives: To evaluate the effects of hormone therapy (HT) on BMD in Korean postmenopausal women.
Methods: From 2003 to 2008, a total of 195 HT group and 203 control group recruited. Treatment were (1) estrogen with cyclic addition of progesterone; (2) estrogen with continuous addition of progesterone; (3) estrogen only; and (4) no treatment. Lumbar (L2-L4) and femur bone mineral densities (BMD) were determined by dual energy X-ray absorptiometry at baseline, after 6, 12, and 24 month of treatment. In these analyses, we adjusted for age and body mass index. Data were expressed as mean±SEM.
Results: Compared with control, BMDs at both lumbar spine and femur neck at 24 month were significantly higher in women under HT. BMD change with HT was negatively correlated with baseline BMD. There were no significant differences in both spine and femur BMDs among the 3 active treatment groups except in femur BMD at 12 month.
Conclusion: This study confirms the long-term preventive effect of HT on BMD loss. This study suggests no difference in BMD response between estrogen alone and addition of combined estrogen-progesterone therapy. The notions that basal bone density affect the response to HT and that a significant response is obtained in the patient with low BMD should provied useful decision-making information for the identification of candidates for HT.
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KEYWORD
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Hormone therapy, Estrogen, Progesterone, Bone mineral density, Osteoporosis
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